Understanding the Nature of Asthma Exacerbations in Patients on Tezepelumab – Raphael Birch (2025)

Tezepelumab is a biologic for severe asthma that reduces exacerbations by blocking TSLP, a cytokine which drives T2 and non-T2 inflammatory pathways. This benefits more patients than biologics that target T2 alone. My SSC investigated why some patients receiving Tezepelumab still exacerbate, by comparing biomarkers at baseline and during attacks.